Researchers in the University of Bonn treated mice with Viagra and made a fantastic discovery: The drug converts unwanted white fat cells and may therefore possibly melt the unwanted “spare tire” around the midriff. Additionally, the material also reduces the chance of other complications due to obesity.
The outcomes are actually printed in The Journal of the Federation of American Societies for Experimental Biology (FASEB).
Sildenafil – known as Viagra – can be used to take care of impotence problems. This material prevents degradation of cyclic guanosine mono-phosphate (cGMP), which in turn ensures blood supply for an erection. Yet, another effect of Viagra continues to be found quite a while past – mice given sildenafil over longer lengths of time were immune to obesity when fed with high fat diet. But, the cause because of this decreased weight gain had not been clear. Researchers in the University of Bonn have had the opportunity to shed some light on this particular effect that was sildenafil. “We happen to be studying the impact of cGMP on fat cells for quite a while now,” reports Prof. Dr. Alexander Pfeifer, Director of the Institute for Pharmacology and Toxicology at the University of Bonn. “This is the reason why sildenafil was a possibly interesting candidate for us.”
Unwanted white fat cells are converted by viagra into beige ones
Jointly with the PharmaCenter of the University of Bonn, the German Federal Institute for Drugs and Medical Devices (BfArM), as well as the Max Planck Institute for Heart and Lung Research, the team around Prof. Pfeifer examined the effect of sildenafil on fat cells in mice. The researchers administered the drug that was potency for seven days to the rodents. “The effects were fairly astounding,” says Dr. Ana Kilic, one of Prof. Pfeifer’s co-workers. Sildenafil raised the conversion of white fat cells, which are seen in individual ‘issue areas’, into beige ones in the creatures. “Beige fat cells burn off the power from ingested food and convert it to heat, says Prof. Pfeifer. As the beige fat cells can “melt the fat” and so fight obesity, research workers have become optimistic for his or her possible.
Favorable impact on inflammation reactions
Additionally, the researchers found something of interest. If white fat cells are additionally “stuffed”/collecting lipids, they’re increasing in size and will synthesize and release hormones which then cause inflammation thereby raising the individuals risk for chronic diseases. Such inflammatory reactions may subsequently lead to, e.g., cardiovascular disorders resulting in heart attacks and strokes, as well as cancer and diabetes. “It appears that sildenafil prevented the fat cells in these mice from getting onto that slippery slope,” reports Prof. Pfeifer. All in all, the development of cells that are white appears to be more healthy.
A lot more than half a billion individuals that are overweight world-wide
Worldwide, over half a billion folks are overweight. Current study has resulted in interesting starting points for additional research with this mechanism. “Sildenafil isn’t just in a position to minimize erectile difficulties, but additionally, it may decrease the dangers of gaining excessive weight,” says Prof. Pfeifer. The researchers might have found a mechanism that enables converting the unwanted white fat cells in the “great” beige (brownish-like) fat cells that “melt” away extra pounds. Additionally, it may be possible to reduce complications associated with obesity. “But this should be established in additional studies,” adds Dr. Kilic.
Warn against early use
Despite data that is bright, researchers warn people from the fallacy of thinking that taking some sildenafil will work to rapidly lose the excess pounds accumulated on christmas. “We’re now in the basic research phase, and all of the studies happen to be completely performed on mice,” stresses Prof. Pfeifer. It’ll be quite a distance until for reducing white fat cells in people, possibly appropriate drugs is likely to be discovered.